Trehalose-based lipid improves mRNA vaccine safety
نویسندگان
چکیده
Abstract The rapid development of lipid nanoparticle (LNP)-formulated mRNA vaccines strongly contributed to overcoming the COVID-19 pandemic. However, in parallel with this success, toxicity ionizable cationic lipids has emerged as a potential issue clinical safety because it might cause vaccine side effects, including myocarditis, anaphylaxis, and pericarditis. In study, reduce risk posed by lipids, we employed LNPs containing trehalose-based (LNP-126), which increased stability LNP-mRNA molecules. Trehalose been shown improve heart function increase through hydrogen bond interactions. LNP-126 was formulated 50% fewer than commercial LNP (LNP-128). Furthermore, encoding reporter gene encapsulated so that expression (Renilla luciferase) organ could be examined. We also assessed immune efficiency immunizing mice had treated an LNP-126-formulated expressing influenza hemagglutinin (HA). results showed reduced liver compared LNP-128, while maintaining vivo. conclusion, LNP-126, will facilitate safer beyond current barriers. A grant (22213MFDS421) from Ministry Food Drug Safety 2022 supported research
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.223.22